Mapping Memory. Protecting What's Human.

We study how chromatin, synapses, and neural circuits work together to shape memory, helping uncover the biological foundations of mental health, neurological disease, and what makes us who we are.

Memory allows us to learn, adapt, build relationships, and carry our experiences through life. Yet despite its central role in who we are, we still don’t fully understand how memory is formed, maintained, and lost.

Our research investigates how connections across chromatin, synapses, and neural circuits give rise to memory and how disruptions in these systems contribute to neurological disease. By studying these relationships across multiple scales of the brain, we seek to better understand memory dysfunction and help uncover new paths toward treatment.

Our Research

Our Expertise

We investigate the structure-function relationships that connect chromatin, synapses, and neural circuits, using interdisciplinary approaches to better understand memory and brain function.

  • Chromatin
  • 3d Genome Folding
  • Neurobiology
  • Synaptic Plasticity
  • Neuroplasticity
  • Neuroepigenetics
  • Neural Connectomes
  • Spatial Technology Development
  • Genome Structure-function
  • Synapse Structure-function

By connecting discoveries across these areas, we can study memory as an integrated system rather than a collection of isolated parts. This perspective helps reveal how changes at one level of the brain can influence function across the whole.

Proud Partners

Scientific discovery is a collaborative effort. We are grateful for the organizations, institutions, and supporters whose partnership helps make this work possible.

Our People

We believe the best ideas emerge when diverse expertise, curiosity, and collaboration come together around a shared question.

Our lab brings together researchers from neurobiology, genomics, engineering, computation, and technology development to explore memory from multiple perspectives.

Meet Our team

Join Us

We’re always looking for curious, collaborative people who want to push the boundaries of neuroscience and memory research. Explore opportunities to contribute, learn, and help shape the future of discovery.

Lab Updates

News, milestones, publications, events, and discoveries from across the Cremins Lab community.

April 2025

Han-Seul Ryu presents MSTP grand rounds entitled ‘Babies, biomarkers, and the Philadelphia Tooth Fairy Project: exploring the consequences of lead poisoning across lifespan.

April 2025

Kenneth Pham gave a great talk on his work to the UPenn Genetics, Epigenetics, and Gene expression communities on his work in heterochromatin mosaicism in fragile X syndrome.

March 2025

Congratulations to MSTP student Han-Seul Ryu for the acceptance of her collaborative paper with the Anguera Lab entitled “B cell stimulation changes the structure and higher-order organization of the inactive X chromosome” in Cell Reports. Amazing job Han-Seul!

February 2025

Congratulations to PhD student Rohan Patel for the acceptance of his paper entitled ”FISHnet: Detecting chromatin domains in single-cell sequential Oligopaints imaging data” in Nature Methods.

January 2025

Congratulations to clinical fellow and postdoc alum Michael Guo on the publication of his paper entitled ‘Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease’ in Nature Communications.'

January 2025

Sweety Meel joins us from Dimple Notani’s lab as a new postdoctoral research fellow. Welcome Sweety!

Our Funding

Our work is supported by the New York Stem Cell Foundation,the Alfred P. Sloan Foundation, the National Science Foundation, the NationalInstitute of Mental Health, the National Institute of Neural Disorders andStroke, the National Science Foundation (NSF), NIH Common fund initiatives, theFriedreich’s Ataxia Research Alliance, the Chan Zuckerberg Initiative (CZI),the Cure Huntington’s Disease Initiative (CHDI), and the NIH 4D Nucleome CommonFund Initiative.