Mapping Memory. Protecting What's Human.

We study how chromatin, synapses, and neural circuits work together to shape memory, helping uncover the biological foundations of mental health, neurological disease, and what makes us who we are.

Memory allows us to learn, adapt, build relationships, and carry our experiences through life. Yet despite its central role in who we are, we still don’t fully understand how memory is formed, maintained, and lost.

Our research investigates how connections across chromatin, synapses, and neural circuits give rise to memory and how disruptions in these systems contribute to neurological disease. By studying these relationships across multiple scales of the brain, we seek to better understand memory dysfunction and help uncover new paths toward treatment.

Our Research

Our Expertise

We investigate the structure-function relationships that connect chromatin, synapses, and neural circuits, using interdisciplinary approaches to better understand memory and brain function.

  • Chromatin
  • 3d Genome Folding
  • Neurobiology
  • Synaptic Plasticity
  • Neuroplasticity
  • Neuroepigenetics
  • Neural Connectomes
  • Spatial Technology Development
  • Genome Structure-function
  • Synapse Structure-function

By connecting discoveries across these areas, we can study memory as an integrated system rather than a collection of isolated parts. This perspective helps reveal how changes at one level of the brain can influence function across the whole.

Proud Partners

Scientific discovery is a collaborative effort. We are grateful for the organizations, institutions, and supporters whose partnership helps make this work possible.

Our People

We believe the best ideas emerge when diverse expertise, curiosity, and collaboration come together around a shared question.

Our lab brings together researchers from neurobiology, genomics, engineering, computation, and technology development to explore memory from multiple perspectives.

Meet Our team

Join Us

We’re always looking for curious, collaborative people who want to push the boundaries of neuroscience and memory research. Explore opportunities to contribute, learn, and help shape the future of discovery.

Lab Updates

News, milestones, publications, events, and discoveries from across the Cremins Lab community.

September 2026

Dr. Clooney Cheng joined the Cremins Lab from Hong Kong as a postdoctoral research fellow.

August 2026

Ken Chandradoss published a collaborative study with Jane Skok’s lab at NYU in Nature Communications, “Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma.” The work examines how DNA damage can drive persistent chromatin changes, including long-range trans interactions.

August 2026

Avi Waldman co-authored a collaborative study published in Cell, “Integrative spatial profiling of 3D genome organization and gene expression in tissue.” The study developed an approach for spatial Hi-C profiling directly in tissue and represents Avi’s first middle-author publication from his graduate work.

August 2026

Phuc Nguyen was selected as a recipient of WashU’s Ann W. and Spencer T. Olin-Chancellor’s Fellowship, a university-wide graduate fellowship.

July 2026

Thomas Malachowski successfully defended his PhD work identifying Megabase-scale heterochromatin domains linked to synaptic gene silencing in fragile X syndrome. Congratulations, Dr. Malachowski!

July 2026

Grace Newell and Emma Costantini joined the lab through the SEEDs-BRIDGE program.

April 2026

Yibo Chen successfully defended his PhD dissertation and joined the lab as a research scientist.

April 2026

Phuc Nguyen joined the Cremins Lab as a WashU graduate student.

Our Funding

Our work is supported by the New York Stem Cell Foundation,the Alfred P. Sloan Foundation, the National Science Foundation, the NationalInstitute of Mental Health, the National Institute of Neural Disorders andStroke, the National Science Foundation (NSF), NIH Common fund initiatives, theFriedreich’s Ataxia Research Alliance, the Chan Zuckerberg Initiative (CZI),the Cure Huntington’s Disease Initiative (CHDI), and the NIH 4D Nucleome CommonFund Initiative.