The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Sep 22, 2016

Lindsey Fernandez wins second place and a $100,000 grant in the 2016 Student Technology Prize for Primary Healthcare through Massachusetts General Hospital’s Ambulatory Practice of the Future. Congratulations, Lindsey!

Sep 22, 2016

We welcome Jingjing Ma to the lab as our lead genomics research scientist and administrative specialist. Welcome Jingjing!

Sep 22, 2016

We welcome Zhendong Cao to the lab for his Fall 2016 rotation. Welcome Zhendong!

Sep 7, 2016

Cremins presents the lab’s work at the Johns Hopkins University McKusick-Nathans Institute of Genetic Medicine.

Aug 26, 2016

Cremins presents at the 4D Nucleome consortium’s scientific webinar series.

Aug 4, 2016

Shawn Srolovitz, Jackie Valeri and Caroline Lachanski receive bronze, silver and gold metals, respectively, at the UPenn undergraduate research symposium!

Aug 4, 2016

Shawn, Jackie and Caroline present at the UPenn Summer Undergraduate Research Symposium.

Jul 11, 2016

Congratulations Thomas Gilgenast – recipient of a NIH Ruth L. Kirschstein Institutional National Research Service Award for predoctoral trainees!

Jun 20, 2016

Kate Titus joins the lab as a full time bioinformatician. Welcome, Kate.

Jun 1, 2016

Cremins presents at the New York Stem Cell Foundation New Innovators Retreat in Montauk, NY

logos  

 

Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.