The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Miriam Minsk is a 2018 Rachleff Scholar. Congratulations, Miriam!

Jennifer presents the lab’s work at the International Society for Stem Cell Research Annual Meeting in Melbourne, Australia.

Jennifer presents the lab’s work at the New York Stem Cell Foundation Investigators Retreat in Montauk, NY

We welcome MD/PhD students Ryan Boe and Jessica Lam for their Independent Studies and Summer rotations!

Congratulations to James Sun for his acceptance into New York University’s MD program!

Sai Phyo passes his qualifying exam. Congratulations Ph.D. candidate, Sai!

Jennifer presents the lab’s work at University of Washington’s Bioengineering Department in Seattle, WA

Congratulations to Sunny Chen for her acceptance into Ohio State’s MD program!

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.