The Cremins lab aims to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements.

Apr 28, 2022

Harshini Chandrashekar speaks on her work at Penn’s NeuroEpigenetics interest group.

Apr 26, 2022

Jon Beagan’s paper on cohesin-independent loops during neural stimulation is accepted at eLIFE!

Apr 26, 2022

Dan Emerson and Ashley Cook’s paper on cohesin-mediated loops and human replication origins is accepted at Nature!

Apr 14, 2022

Zoltan Simandi speaks on his work at Penn’s Epigenetics Institute

Apr 10, 2022

Jordan Barnett’s collaborative work with the Joyce lab is available on BioRxiv: https://doi.org/10.1101/2022.04.08.487672

Apr 4, 2022

Avi Waldman and Rohan Patel receive Honorable Mentions for the NSF GRFP – congratulations!

Mar 18, 2022

Linda Zhou matches at her first choice for residency – UPenn Dermatology

Feb 16, 2022

Alexandria Nikish is the recipient of the UPenn T32 Neurotechnology training grant. Congratulations Ali!

Feb 11, 2022

Miriam Minsk is accepted into USCF, Johns Hopkins, and Tri-I MD/PhD programs – congratulations Miriam!

Jan 27, 2022

Ken Chandradoss speaks on his work at Penn’s Epigenetics Institute

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  Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, the National Institute of Mental Health, the National Institute of Neural Disorders and Stroke, NIH Common fund initiatives, the Friedreich’s Ataxia Research Alliance, the Chan Zuckerberg Initiative, and the NIH 4D Nucleome Common Fund Initiative.