The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Caroline Lachanski receives College House Research Fellowship

Mayuri Rege joins the lab as a Postdoctoral scholar. Welcome, Mayuri.

Shawn Srolovitz wins Vagelos Undergraduate Research Grant

Cremins presents at Hartwell Foundation in Charlotte, NC

Cremins presents at Jackson Laboratories at Workshop on 3D Genome Mapping Technology

Cremins presents at the NIH 4D Nucleome Kick-off meeting in Bethesda, MD

Thomas Gilgenast passes his qualifying exam. Congratulations, Ph.D. candidate Gilgenast!

Heidi Norton passes her qualifying exam. Congratulations, Ph.D. candidate Norton!

Logo-1

 

Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.