Cremins Laboratory | 3-D Epigenomics and Systems Neurobiology Laboratory

The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Apr 16, 2019

Deepak Mani joins the lab for his first rotation in the Bioengineering graduate program in Fall 2019. Welcome Deepak!

Mar 28, 2019

Alexandria Nikish joins the lab for her Ph.D. studies in Fall 2019. Ali
did her undergraduate degree at MIT and worked at the Broad Institute as
well as CRISPR Therapeutics. Welcome, Ali!

Mar 27, 2019

Thomas Gilgenast’s paper on statistical methods to call loops in 5C data
is now out in Cell Systems:
https://www.cell.com/cell-systems/pdfExtended/S2405-4712(19)30067-5

Mar 21, 2019

Katelyn Titus is accepted into the Bioengineering Ph.D. program and will
transition to a full time graduate student in our lab in Fall 2019.
Congratulations Kate!

Mar 20, 2019

Jennifer presents Mayuri, Ji Hun, and Jon’s work at the 3D genome in
gene regulation and disease meeting in Banff, Canada:
http://www.keystonesymposia.org/19X6

Feb 12, 2019

Congratulations to Linda Zhou on receiving her F31 NIH grant.

Feb 12, 2019

Congratulations to Kate Titus on her acceptance into the Bioengineering
PhD program at UPenn. Kate – we are proud of you!

Feb 12, 2019

Thomas Gilgenast’s manuscript was accepted at Cell Systems.
Congratulations Thomas!

Feb 4, 2019

We welcome Harshini Chandrashekar to the lab. Welcome, Harshini!

Jan 18, 2019

The lab’s work is highlighted by the NIH common fund.

Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.