The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Sep 6, 2019

Jon Beagan is the recipient of the best poster award at the 2019 Penn
Genetics retreat. Congratulations Jon, you make us so proud!

Aug 26, 2019

Our team is the recipient of the National Science Foundation Emerging Frontiers in Research Innovation grant for chromatin and epigenetic engineering (2019-2023) in collaboration with Casey Brown and Arjun Raj.

Aug 26, 2019

Our team receives an R01 through the National Institute of Mental Health (2019-2024).

Aug 19, 2019

Katelyn Titus joins the lab for her Ph.D. studies in Bioengineering. Welcome, Kate!

Aug 19, 2019

Chuanbin Su joins the lab as a postdoctoral scholar. Welcome, Chuanbin!

Aug 19, 2019

Alexandria Nikish joins the lab for her Ph.D. studies. Welcome, Ali!

Aug 10, 2019

Linda Zhou from the Cremins lab is the recipient of an NIH F30 Grant 
starting September 2019. Congratulations Linda!

Aug 2, 2019

Zoltan Simandi and Harshini Chandrasekhar attend the Columbia single cell sequencing analysis boot camp.

Aug 1, 2019

Miriam Minsk is the recipient of the best research presentation award for her summer Rachleff scholar’s research. Congratulations to Miriam and her mentor Linda Zhou!

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.