The Cremins lab aims to understand how chromatin works through long-range physical folding mechanisms to encode neuronal specification and long-term synaptic plasticity in healthy and diseased neural circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging, optogenetics, genome engineering, induced pluripotent stem cell differentiation to neurons/organoids, and in vitro and in vivo electrophysiological measurements.

Harshini Chandrashekar speaks on her work at Penn’s NeuroEpigenetics interest group.

Jon Beagan’s paper on cohesin-independent loops during neural stimulation is accepted at eLIFE!

Dan Emerson and Ashley Cook’s paper on cohesin-mediated loops and human replication origins is accepted at Nature!

Zoltan Simandi speaks on his work at Penn’s Epigenetics Institute

Jordan Barnett’s collaborative work with the Joyce lab is available on BioRxiv:

Avi Waldman and Rohan Patel receive Honorable Mentions for the NSF GRFP – congratulations!

Linda Zhou matches at her first choice for residency – UPenn Dermatology

Alexandria Nikish is the recipient of the UPenn T32 Neurotechnology training grant. Congratulations Ali!

Miriam Minsk is accepted into USCF, Johns Hopkins, and Tri-I MD/PhD programs – congratulations Miriam!

Ken Chandradoss speaks on his work at Penn’s Epigenetics Institute


  Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, the National Institute of Mental Health, the National Institute of Neural Disorders and Stroke, NIH Common fund initiatives, the Friedreich’s Ataxia Research Alliance, the Chan Zuckerberg Initiative, and the NIH 4D Nucleome Common Fund Initiative.