The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Jon’s review in WIREs Systems Biology and Medicine was one of the Top Ten accessed in 2016

We welcome Jenny Luppino, Linda Zhou, and Daniel Park to the lab for their Spring 2017 rotations. Welcome Jenny, Linda, and Daniel!

Cremins attends the Twenty-eighth Annual Kavli Frontiers of Science Symposium in Irvine, CA and is selected as a 2016 Kavli Fellow 2016.

Cremins attends the New York Stem Cell Foundation Translational Stem Cell Research conference at Rockefeller.

Cremins attends 4D Nucleome Annual meeting in San Diego, CA.

Heidi Norton’s poster wins third place at the Penn Institute for Computational Science (PICS) symposium!

Heidi Norton presents a short-talk and poster at the Penn Institute for Computational Science (PICS) symposium.

Lindsey Fernandez wins second place and a $100,000 grant in the 2016 Student Technology Prize for Primary Healthcare through Massachusetts General Hospital’s Ambulatory Practice of the Future. Congratulations, Lindsey!

We welcome Jingjing Ma to the lab as our lead genomics research scientist and administrative specialist. Welcome Jingjing!

We welcome Zhendong Cao to the lab for his Fall 2016 rotation. Welcome Zhendong!



Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.