The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Sep 24, 2018

We welcome Patrick Paglia, a work-study student, to the lab. Welcome, Patrick!

Sep 22, 2018

We welcome Miriam Minsk, an undergraduate student, to the lab. Welcome, Miriam!

Sep 22, 2018

We welcome Chunmin Ge to the lab as a senior technician. Welcome, Chunmin!

Sep 22, 2018

We welcome Sean Louzon to the lab for his Fall 2018 rotation. Welcome, Sean!

Aug 28, 2018

Katelyn Titus is promoted to Senior Computational Research Specialist. Congratulations, Kate!

Aug 27, 2018

Jennifer presents the lab’s work at the University of Pittsburgh.

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.