The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Deepak Mani joins the lab for his second rotation. Welcome Deepak!

Jennifer presents the lab’s research at Washington University St. Louis.

Our alumnus James Sun has been accepted into NYU’s PhD program and will
pursue an MD/PhD at NYU. Congratulations James!

Dr. Heesun Choi joins our team as a postdoctoral scholar. Welcome Heesun!

Jennifer presents our lab’s work at MIT.

Jon Beagan is the recipient of the best poster award at the 2019 Penn
Genetics retreat. Congratulations Jon, you make us so proud!

Our team is the recipient of the National Science Foundation Emerging Frontiers in Research Innovation grant for chromatin and epigenetic engineering (2019-2023) in collaboration with Casey Brown and Arjun Raj.

Our team receives an R01 through the National Institute of Mental Health (2019-2024).

Katelyn Titus joins the lab for her Ph.D. studies in Bioengineering. Welcome, Kate!



Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.