Cremins Laboratory | 3-D Epigenomics and Systems Neurobiology Laboratory

The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Feb 12, 2019

Congratulations to Linda Zhou on receiving her F31 NIH grant.

Feb 12, 2019

Congratulations to Kate Titus on her acceptance into the Bioengineering
PhD program at UPenn. Kate – we are proud of you!

Feb 12, 2019

Thomas Gilgenast’s manuscript was accepted at Cell Systems.
Congratulations Thomas!

Jan 18, 2019

The lab’s work is highlighted by the NIH common fund.

Jan 16, 2019

Kate Titus is accepted into the Genomics and Computational Biology Ph.D.
program. Congratulations Kate!

Jan 16, 2019

Jennifer presents the lab’s work at Duke University.

Dec 19, 2018

Lindsey and Thomas are lead authors on their new Bioarxiv preprint
“3DeFDR: Identifying cell type-specific looping interactions with
empirical false discovery rate guided thresholding.“

Dec 7, 2018

Linda and James’ work on the 3D genome and trinucleotide repeat expansion disorders is highlighted by the NIH common fund.

Dec 7, 2018

Jennifer presents Linda and James’ work on the 3D genome and trinucleotide repeat expansion disorders at the joint 4DNucleome-ASCB satellite meeting in San Diego, CA.

Dec 6, 2018

Jennifer presents Mayuri and Ji Hun’s work on engineering loops with light at the 4D Nucleome annual meeting in San Diego, CA.

Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.