Cremins Laboratory | 3-D Epigenomics and Systems Neurobiology Laboratory

The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Jun 4, 2019

Jennifer presents the lab’s work at the Evolution and
Function of higher-order chromosomes meeting at the Institut Pasteur in
Paris France.

Jun 3, 2019

Jennifer presents the lab’s work at the European Molecular
Biology Laboratory in Heidelberg, Germany.

May 28, 2019

Ji Hun Kim travels to Greece to present a podium talk on his
Light Activated Dynamic Looping technology. Congratulations Ji Hun!

May 8, 2019

Jennifer presents the lab’s work at the University of Chicago.

May 6, 2019

Jennifer presents the lab’s work at the University of Virginia
Medical School Annual Symposium: Higher-order structure and disease.

Apr 16, 2019

Deepak Mani joins the lab for his first rotation in the Bioengineering graduate program in Fall 2019. Welcome Deepak!

Apr 13, 2019

Jennifer presents the lab’s work at the Company of
Biologists Epigenetics Meeting in Sussex UK.

Mar 29, 2019

Thomas Gilgenast successfully defends his thesis proposal.

Mar 28, 2019

Alexandria Nikish joins the lab for her Ph.D. studies in Fall 2019. Ali
did her undergraduate degree at MIT and worked at the Broad Institute as
well as CRISPR Therapeutics. Welcome, Ali!

Mar 27, 2019

Thomas Gilgenast’s paper on statistical methods to call loops in 5C data
is now out in Cell Systems:
https://www.cell.com/cell-systems/pdfExtended/S2405-4712(19)30067-5

Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.