The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Jun 12, 2017

Linda wins the UPenn Computational Genetics Training Grant! Congrats Linda!

May 10, 2017

Lindsey Fernandez joins the lab full time. Welcome, Lindsey!

Mar 27, 2017

Jennifer presents the lab’s work at Penn State.

Mar 17, 2017

Lindsey Fernandez is a recipient of the 2017 National Science Foundation Graduate Research Fellowship. Congratulations Lindsey!

Mar 10, 2017

Linda Zhou – MD/PhD student in the GCB program – joins the lab. Welcome Linda.

Mar 6, 2017

Jennifer presents the lab’s latest work at the Gladstone Institute in San Francisco, CA.

Jan 24, 2017

Jon’s review in WIREs Systems Biology and Medicine was one of the Top Ten accessed in 2016

Dec 12, 2016

We welcome Jenny Luppino, Linda Zhou, and Daniel Park to the lab for their Spring 2017 rotations. Welcome Jenny, Linda, and Daniel!

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.