The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Jennifer presents Linda and James’ work on the 3D genome and trinucleotide repeat expansion disorders at the joint 4DNucleome-ASCB satellite meeting in San Diego, CA.

Jennifer presents Mayuri and Ji Hun’s work on engineering loops with light at the 4D Nucleome annual meeting in San Diego, CA.

Dan Emerson gives his very first talk on a big stage at the 4D Nucleome annual meeting in San Diego, CA. Congratulations Dan!

We welcome Di Zhang, M.D./Ph.D. candidate from the Blobel lab, as a visiting
scientist this semester.

Jon gives a talk on his work at the Epigenetics Institute retreat.

Linda presents a poster at the Epigenetics Institute Retreat.

Ravi Boya, PhD, joins us for his postdoc. Welcome, Ravi!

Jennifer presents the lab’s work at New York University.

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.