The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Congratulations to Jesi Kim for her admission to Harvard Medical School’s 2016 Harvard-MIT Health Sciences and Technology (HST) program. We are proud of her for this tremendous achievement!

Congratulations to Shawn Srolovitz and Caroline Lachanski – recipients of the 2016 Little John Undergraduate Research Fellowship.

Congratulations Michael Duong – recipient of the Spring 2016 Ernest M. Brown, Jr. College Alumni Society Undergraduate Research Grant!

Caroline Lachanski is the recipient of the 2016 Benjamin Franklin Society Award

The lab’s first primary research paper is provisionally accepted in Cell Stem Cell! Congratulations to the entire iPS team (Jon Beagan, Jesi Kim, Thomas Gilgenast, Heidi Norton and Gui Hu).

Jon’s review paper “CRISPR/Cas9 genome editing throws descriptive 3-D genome folding studies for a loop” is accepted in WIREs Systems Biology and Medicine.

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.