The Cremins lab investigates the epigenetic mechanisms regulating development and function of the mammalian central nervous system. We map and analyze neuronal epigenomes in three-dimensions using quantitative, genome-wide technologies. We also perturb epigenomes by employing state-of-the art genetic engineering strategies (e.g. CRISPR/Cas9, optoepigenetics). To test our hypotheses, we primarily use embryonic and induced pluripotent stem cell models of neuronal differentiation and disease. Our long-term goal is to discover how genome architecture controls genome function, applying this to study fundamental mechanisms controlling neuronal phenotype and, by extension, the onset and progression of neurodegenerative and neurodevelopmental disease states.

Jennifer presents Jon’s new work exploring the 3D genome in neuronal activation at the 4DN Annual Meeting in Washington D.C.

Jennifer presents the lab’s work at the NIH Center of Excellence in Chromatin Biology

Jennifer presents the lab’s work at the NIH/NICHD Division of Developmental Biology

Jennifer presents the lab’s research at Washington University St. Louis.

Our alumnus James Sun has been accepted into NYU’s PhD program and will
pursue an MD/PhD at NYU. Congratulations James!

Dr. Heesun Choi joins our team as a postdoctoral scholar. Welcome Heesun!

Jennifer presents our lab’s work at MIT.

Jon Beagan is the recipient of the best poster award at the 2019 Penn
Genetics retreat. Congratulations Jon, you make us so proud!

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Our work is supported by the New York Stem Cell Foundation, the Alfred P. Sloan Foundation, the National Science Foundation, an NIH New Innovator Award through the National Institute of Mental Health and the NIH 4D Nucleome Common Fund Initiative.